BioSurgery Advancing Surgery, Enhancing Life

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The Simple Solution For Reducing Adhesions

Adept

ADEPT® Adhesion Reduction Solution [4% Icodextrin] is indicated for use intraperitoneally as an adjunct to good surgical technique for the reduction of post-surgical adhesions in patients undergoing gynecological laparoscopic adhesiolysis.

The Burden of Adhesions

  • Adhesions are a significant cause of infertility in women5,8, are a major cause of post operative pain6, and are the most common cause of intestinal obstruction3
  • 1994 U.S. hospital discharge data revealed that adhesiolysis procedures accounted for 846,415 inpatient days and cost $1.3 billion in hospitalization and surgeon expenditures. Compared with all inpatients, adhesiolysis patients were disproportionately young and female (data not shown). Females represented the majority of adhesiolysis patients at 83% versus all inpatients at 60%4

How Adept® Works

  • ADEPT® provides a temporary separation of peritoneal surfaces by hydroflotation as a result of maintaining a fluid reservoir. This colloidal osmotic action of icodextrin allows the retention of a reservoir of fluid within the peritoneal cavity for 3-4 days. 1,7
  • ADEPT® minimizes tissue apposition during the critical period of fibrin formation and mesothelial regeneration following surgery, thereby providing a barrier to adhesion formation 1

Easy to Use

  • Requires no significant change to surgical routine 2
  • Does not impair tissue handling and visibility of the surgical field 2



ADEPT® Adhesion Reduction Solution [4% Icodextrin]

ADEPT® Adhesion Reduction Solution is indicated for use intraperitoneally as an adjunct to good surgical technique for the reduction of post-surgical adhesions in patients undergoing gynecological laparoscopic adhesiolysis.

ADEPT® Instructions For Use

Important ADEPT® Safety Information

Order Information

Order # Description
0600041 ADEPT® Adhesion Reduction Solution
Box of 5 bags
1.5L each

Adept To order, call 1-800-423-2090 or contact your local Baxter representative

ADEPT is a registered trademark under license from Innovata plc.

References

  1. ADEPT® Adhesion Reduction Solution [4% Icodextrin] Instructions for Use, 6208501EH01.
  2. Sutton C., Minelli L., Garcia E., et al.  Use of icodextrin 4% solution in the reduction of adhesion formation after gynaecological surgery, Gynecol Surg 2005 2: 287-296.
  3. Al Took S., Platt R., Tulandi T.  Adhesion-related small-bowel obstruction after gynecologic operations. Am J Obstet Gynecol 1999; 180: 313-5.
  4. Ray N., Denton W., Thamer M., Henderson S., Perry S. Abdominal Adhesiolysis Inpatient Care and Expenditures in the United States in 1994. J Am Coll Surg 1998; 186:1-9.
  5. Mishell D.R., Davajan V. Evaluation of the infertile couple. In: Mishell D.R., Davjan V., Lobo R.A., eds. Infertility Contraception & Reproductive Endocrinology. 3rd edition. Massachusetts: Blackwell Scientific Publications Inc., 1991:557-70. 
  6. diZerega G.S. Biochemical events in peritoneal tissue repair. Eur J Surg Suppl 1997; 577: 10-16.
  7. Hosie K., Gilbert J.A., Kerr D., Brown C.B., Peers E.M. Fluid dynamics in man of an intraperitoneal drug delivery solution: 4% icodextrin. Drug Deliv 2001; 8: 9-12.
  8. Diamond M.P., Freeman M.L. Clinical implications of postsurgical adhesions. Hum Reprod Update 2001; 7: 567-76.