Preparation Instructions1

ADEPT^® is administered directly into the peritoneal cavity during laparoscopic gynecological surgery, being used as an irrigant solution during the course of surgery. Once the surgeon has completed the surgical procedure(s), the cavity is aspirated of all remaining fluid. A final volume of 1 liter of ADEPT^® is then introduced into the cavity before removal of the scope.

Using standard operating technique:

1. ADEPT^® should be warmed to approximately body temperature prior to use, using a device specifically intended for warming solutions in operating rooms.
2. Remove the outer wrap from the ADEPT^® bag and hang the sterile bag of solution on an I.V. pole.
3. Remove the twist-off tab from the spike port and insert a giving set for connection to a laparoscope.
4. ADEPT^® should be used intra-operatively as an irrigant solution, and as a post-operative instillate. The solution will flow through a giving set and through laparoscopes.
5. When used as an intra-operative irrigant solution, at least 100 mL of ADEPT^® should be introduced to the cavity every 30 minutes.
6. Remove remaining fluid before introducing the final instillation.
7. For the final instillation of ADEPT^®, prior to removal of the laparoscope, one liter (a new bag of ADEPT^® if 1 liter bags are being used) should be used. Direct the solution at the operative sites in the first instance, the remainder being distributed throughout the cavity.
8. Dispose of the bag and any unused portion of the solution following normal operating room biological hazard procedures.

References

1. ADEPT^® Adhesion Reduction Solution [4% Icodextrin] Instructions for Use, 6208501EH01.