How ADEPT^® Works

ADEPT^® keeps the peritoneal surfaces apart during the critical post-surgery period when the patient is at the greatest risk of adhesion formation. This minimizes tissue apposition during the critical period of fibrin formation and mesothelial regeneration following surgery, thereby providing a barrier to adhesion formation.

Icodextrin, as an alpha (1-4)-linked glucose polymer, is similar in structure to carbohydrates which occur physiologically. When administered intraperitoneally as a 4% solution, icodextrin functions as a colloid osmotic agent. This colloidal osmotic action of icodextrin allows the retention of a reservoir of fluid within the peritoneal cavity for 3-4 days.1^,2

The Structural Formula of Icodextrin2

The icodextrin solution provides a fluid reservoir in the peritoneal cavity at an extended duration of up to 4 days.  Icodextrin is metabolized by amylase and is absorbed at a slow rate by the lymphatic system into the systemic circulation. It is then broken down by amylase and metabolized to glucose (40 g glucose/L of Adept). 1^,3

References

1. Hosie K., Gilbert J.A., Kerr D., Brown C.B., Peers E.M. Fluid dynamics in man of an intraperitoneal drug delivery solution: 4% icodextrin. Drug Deliv 2001; 8: 9-12.
2. ADEPT Adhesion Reduction Solution [4% Icodextrin] Instructions for Use, 6208501EH01.
3. Brown C., Luciano A., Martin D., Peers E., et al.  Adept (icodextrin 4% solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomized, controlled study. Fertility and Sterility, In Press, Corrected Proof, Available online 26 March 2007.